Yes. Vastu may have an effect on your career. The problematic zones could be North & East. N & E sides should not have common walls. These sides should be having windows, which can be opened. You should keep the windows in North & East always opened.
Also ensure there are no staircases (both internal and external), Pooja room, High ceiling, Bathroom/Lavatory, Store room/Kitchen/Portico, Sewage/septic tank, Trees,Inverter/Generator, Over-head water storage tank, in the North-east.
Internal staircase and external closed staircase, Pooja room, Kitchen, Bathroom/Lavatory, Windows/doors/openness of any nature, Inverter/Generator, Low ceiling, Sewage/septic tank, Corner cut Portico, T Junction, Well/Bore, Pit/Dimple/Dent, should not be prevailing in the South-West direction.
Pls check on these aspects and rectify to have a prosperous life.